An overdose of aspirin means you have to much aspirin in your body. This can happen in two ways: If a person accidentally or intentionally takes a very large dose of aspirin at one time, it's called an acute overdose. If a normal daily dose of aspirin builds up in the body over time and causes symptoms, it's called a chronic overdose. This may happen if your kidneys do not work correctly or when you are dehydrated. Chronic overdoses are usually seen in older patients during hot weather. This is for information only and not for use in the treatment or management of an actual poison exposure. If you have an exposure, you should call your local emergency number (such as 911) or 1-800-222-1222 to find a local poison control center near you.